A heartfelt thank you to all who joined us virtually and in person for the 2025 cureCADASIL Patient-Investigator Meeting.

From powerful patient stories to exciting progress from leading CADASIL researchers, the meeting was a fantastic day full of learning, connection with the community, and the shared goal of finding a cure for #CADASIL.

We’re grateful to our speakers, Community Advisory Group members, and all of the participants who made this event a success.

Watch the 2025 PIM Conference Recording

Click the links below to view a specific presentation.

0:00 – Welcome and Introduction, Bert Kasiske

2:01 – Living with CADASIL, Ki Coale

28:36 – The Year in Review, Nikolaos Karvelas

45:03 – What can the heterogeneity of CADASIL tell us about prediction of clinical course impact on treatments, now and in the future?, Bert Kasiske

47:55 – Genotype-based risk stratification in NOTCH3-associated small vessel disease, including CADASIL, Julie Rutten

1:09:07 – CADASIL Heterogeneity: How it affects development of therapies, Micheal Wang

1:27:32 – Ongoing CADASIL studies in the US, Jane Gunther

1:53:32 – The CADASIL Consortium, Karen Orjuela

1:55:30 – NIH/NHLBI Study, Elisa Ferrante

2:03:08 – CZI Patient-Partnered Collaboration for Rare Neurodegenerative Disease, Fanny Elahi

2:14:42 – CADASIL Community Natural History Study, Bert Kasiske

2:26:58 – Clinical trials past, present and future, Jane Gunther & Fanny Elahi

2:35:11 – Panel of patients & investigators