To highlight research advancements cureCADASIL Association hosted a series of webinars called CADASIL Connection. These informative, pre-recorded webinars are unique opportunities to educate and connect the audience of researchers, clinicians, and patients on current research and developments in CADASIL. Each link below will ask for your name and email address, then you will have access to the recording.

WATCH OUR WEBINARS

CADASIL Connection Webinar Recording – November 2022

Fanny Elahi, MD, PhD

The CADASIL Patient-Partnered Therapeutic Discovery Pipeline

Fanny Elahi, MD, PhD, a Physician/Scientist in the Department of Neurology, Neuroscience and Pathology at the Icahn School of Medicine, Mt. Sinai in New York discusses modeling the CADASIL disease process to make discoveries with therapeutic potential.

CADASIL Connection Webinar Recording – July 2022

Jane Paulsen, PhD Michael Geschwind, MD, PhD

Learn about the New $12M NIH-Funded CADASIL Consortium Study

Jane Paulsen, PhD, Professor Neurology at the University of Wisconsin School of Medicine & Public Health and Michael Geschwind, MD, PhD, Michael J. Homer Chair in Neurology at the University of California San Francisco discuss the details about the exciting $12M NIH-Funded CADASIL Consortium Study.

CADASIL Connection Webinar Recording – April 2022

Masayo Koide, MD, PhD

Capillary dysfunction by CADASIL: The smallest vessels have the biggest impact

Dr. Mayaso Koide, PhD, from the Department of Pharmacology, University of Vermont, and recipient of a University of Pennsylvania Orphan Disease Center Million Dollar Bike Ride research grant, presents her research on the impact of CADASIL on brain capillaries and their regulation of cerebral blood flow.

CADASIL Connection Webinar Recording – December 2021

Julie Rutten, MD, PhD

Why do certain individuals with a NOTCH3 mutation develop CADASIL and others do not? Understanding the role of genetic modifiers in NOTCH3 associated small vessel disease

Dr. Julie Rutten, MD, PhD from the Department of Clinical Genetics of the Leiden University Medical Center (LUMC), The Netherlands presents her research on NOTCH3 genetic mutations and their relationship to the clinical presentation of CADASIL.

CADASIL Connection Webinar Recording – April 2021

Fabrice Dabertrand, Ph.D.

Restoring Cerebral Blood Flow in a CADASIL Model

Fabrice Dabertrand, PhD Associate Professor of Anesthesiology and Pharmacology at University of Colorado, Anschutz Medical Campus and recipient of the 2019 Million Dollar Bike Ride (MDBR) seed grant (made possible by donations from the CADASIL community in partnership with cureCADASIL and Penn Medicine Orphan Disease Center) shares insights on cerebral blood flow in a CADASIL mouse model, explains what pericytes are and their role as well as the effects of PIP₂ in increasing blood flow to the brain.

CADASIL Connection Webinar Recording – September 2018

Saskia A.J. Lesnik Oberstein, M.D., Ph.D.

“CADASIL and NOTCH3: Genotyping, Phenotyping and Exon Skipping”

Dr. Lesnik Oberstein, a Clinical Neurogeneticist at the Department of Clinical Genetics of the Leiden University Medical Center (LUMC), The Netherlands, presents new insights into NOTCH3 mutations as well as the current status of her lab’s published exon-skipping gene therapy as a potential therapeutic strategy for CADASIL.

CADASIL Connection Webinar Recording – April 2018

Dr. Michael Wang, M.D., Ph.D.

“Molecular Clues from Cadasil Brain Analysis”

Dr. Wang is Chief of Neurology at the VA Ann Arbor Healthcare System and Professor of Neurology at the University of Michigan where his lab studies the mechanisms of vascular degeneration and defining pathological proteins that build up in CADASIL and here he will share this exciting work in advancing our understanding of CADASIL.

CADASIL Connection Webinar Recording – February 2018

Joseph F. Arboleda-Velasquez, M.D., Ph.D.

“Harnessing the Power of the Immune System to Develop Therapies for CADASIL”

Dr. Joseph Arboleda Velasquez discusses the design and analysis of CADASIL mouse models, recent research findings and establishing feasibility for a novel modality of treatment for cerebral small vessel disease.

CADASIL Connection Webinar Recording – December 2017

Jorge Ortiz Garcia, M.D.

“The Misdiagnosis of CADASIL – One Institutions Experience”

Dr. Jorge Ortiz Garcia, a neurocritical care fellow, provides insight to CADASIL diagnosis and describes one institutions experience with misdiagnosis of this rare disease.

CADASIL Connection Webinar Recording – October 2017

Manfred Boehm, M.D.

“The NIH CADASIL Disease Discovery Program: A Clinical and Basic Research Investigation to Better Understand the Disease”

Dr. Manfred Boehm, Senior Investigator Laboratory of Cardiovascular Regenerative Medicine at the National Heart, Lung, and Blood Institute (NHLBI) and Principal Investigator for the CADASIL Disease Discovery Clinical Trial shares an inside view of the CADASIL Disease Discovery Study being conducted at the National Institute of Health.

CADASIL Connection Webinar Recording – August 2017

Li-Ru Zhao, Ph.D., M.D.

“Exploring a Therapeutic Approach for CADASIL: The Efficacy of Bone Marrow Stem Cell Factors in Brain Repair”

**The sound quality is low for the first several minutes, then the quality is improved for the remainder of the presentation.

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This cureCADASIL webinar series is supported by a grant from Global Genes, generous community donations and time of valued volunteers.

CADASIL Connection Research Webinars