Register Now for the Million Dollar Bike Ride 2025!
We are excited to announce that registration is now open for the Million Dollar Bike Ride 2025, happening on June 14, 2025, at the University of Pennsylvania Campus in Downtown Philadelphia. This event is a vital opportunity to raise funds for CADASIL research and awareness.
Join us in person or virtually and be part of this incredible cause. Sign up today and help us make a difference!
Ways to Participate
Thank you to the members of our community who have already registered to participate in this year’s Million Dollar Bike Ride (MDBR). In the past few years, we have raised over $600,000 for CADASIL Research. It is the most important CADASIL fundraising event of the year. There are three main ways the CADASIL community can help!
1) Participate in Philadelphia
You can choose to create a fundraiser page and participate in-person in Philadelphia – whether as a biker, volunteer or walker (1 mile walk). We need 15 in-person participants to be invited back.
2) Participate Virtually
Create a fundraiser page and participate virtually. There is no formal requirement to actually bike, but most participants take a short walk or bike ride with family & friends. It is a great way to use this special event as a way to fundraise for CADASIL research. If you are unable to come to Philadelphia, this is the best way to participate.
3) Donate
If you are unable to participate in-person or fundraise virtually, you can donate! Thank you!
How to Register
- Go to the MDBR 2025 registration site.
- Select how you would like to participate:
- “In-Person Cyclist – Fundraising Required” – Costs $30 to register and you commit to fundraising at least $250.
- “In-Person Cyclist – Fundraising Optional” – Costs $85 but there is no commitment to fundraising a certain amount.
- Million Dollar Mile – If you would like to walk 1 mile on June 14, 2025. Costs $15 and it does count for in-person participation.
- “Virtual Cyclist” – If you would like to participate but cannot make it to Philly. We highly encourage you to still create a fundraising page, but it is optional.
- “Volunteer” – If you are able to come to Philadelphia but are unable to bike/walk, volunteering is an excellent way to participate. Team CADASIL gets credit for volunteers!
- Make sure to select “Team CADASIL” from the “Disease Team you are riding with” dropdown.
- Happy Fundraising!
Have questions? Email the Team Captain at [email protected]
Support CADASIL Research – Donate to the Million Dollar Bike Ride 2025!
Not riding in the Million Dollar Bike Ride 2025? You can still make a huge impact! Your donation will directly support CADASIL research, bringing us one step closer to better treatments and a cure.
Every dollar raised goes toward funding critical studies that wouldn’t be possible without your help. Join us in making a difference—donate today and help change lives!
Exciting News from the 2024 Million Dollar Bike Ride!
Thanks to the incredible support of the 2024 Million Dollar Bike Ride, an impressive $2.6 million in grants has been awarded to 41 researchers across 34 institutions, advancing studies on 34 rare diseases!
We’re thrilled to announce that Michael Wang, M.D., Ph.D., from the University of Michigan, has been awarded $101,776 for his groundbreaking #CADASIL research: “Small molecule inhibition of NOTCH3 conformational alterations.”
This vital funding brings us closer to breakthroughs for CADASIL and other rare diseases. Together, we’re making a difference!
See all of the grants made possible by the Million Dollar Bike Ride.
MDBR Race Photos 2024


