Get Involved & Take Action
Whether you join a study, donate, ride, fundraise, or simply share your story — every action you take brings the CADASIL community closer to treatments and a cure.
Join a StudyJoin the CADASIL Community Natural History Study
The patient registry is one of the most important tools we have to accelerate research. By joining, you help researchers understand CADASIL better, and you may be matched with clinical studies that need participants like you.
Our Impact Together
Every action moves us forward
Participate in Research
Join a CADASIL Study
Patient participation is the single most important thing you can do to accelerate research. These studies need you — patients, caregivers, family members, and healthy volunteers.
CADASIL Community Natural History Study
This landmark multi-site study is tracking how CADASIL progresses over time — and it cannot succeed without you. Data collected directly informs future clinical trials and is central to cureCADASIL's mission. This study is actively enrolling patients now.
Supported in part by the Chan Zuckerberg Initiative Patient-Partnered Collaborations grant.
CADASIL Community Natural History Study
A multi-site study tracking CADASIL progression over time to build the foundation for future clinical trials and treatment development.
Learn more & joinResearch Studies Overview
A comprehensive overview of all research studies associated with cureCADASIL — including eligibility details and how to sign up.
View overviewSignature Annual Event
2026 Patient-Investigator Meeting
Our 2026 Patient-Investigator Meeting was one of the most important events of the year — bringing patients, caregivers, and leading researchers together in person to connect, share findings, and shape the future of CADASIL research.
Support the Mission
Make a Donation
"cureCADASIL is volunteer-led. With minimal overhead, virtually every dollar you donate goes directly to CADASIL research, patient resources, and advocacy. Give in the way that works best for you."
One-Time Donation
Make an immediate impact with a single gift of any amount.
📈Donate Stock
Donating appreciated stock may offer significant tax advantages.
🤝Corporate Matching
Double your impact — check if your employer matches donations.
📜Planned Giving
Leave a lasting legacy by including cureCADASIL in your estate plans.
➕More Ways to Give
See all donation options and find the right fit for your situation.
Annual Fundraising Event
Million Dollar Bike Ride
Penn Medicine's annual fundraising event for rare disease research. Ride and raise money that directly funds CADASIL breakthroughs.
Ride for CADASIL Research
Create a team, set a fundraising goal, and ride. Every dollar raised goes toward research that brings us closer to treatments and a cure. Individuals, families, and companies are all welcome.
Join the Ride Ride History