Million Dollar Bike Ride — Team CADASIL

Every mile pedaled. Every dollar raised. Every year remembered.

Our Cumulative Impact

$720,349 Total Raised
8 Years Riding
8 Research Grants Funded
2019: First year riding for CADASIL 2020: Virtual ride during COVID — community stayed strong 2021: $120,000+ in pilot research grants awarded 2022: Team grew year over year 2023: MDBR grants announced to advance CADASIL research 2024: Million Dollar Bike Ride Team CADASIL 2025: Thank you for supporting Team CADASIL! 2019: First year riding for CADASIL 2020: Virtual ride during COVID — community stayed strong 2021: $120,000+ in pilot research grants awarded 2022: Team grew year over year 2023: MDBR grants announced to advance CADASIL research 2024: Million Dollar Bike Ride Team CADASIL 2025: Thank you for supporting Team CADASIL! 2026: Fantastic fundraising effortsThank you for supporting Team CADASIL!

Since 2019, Team CADASIL has participated in the University of Pennsylvania's Million Dollar Bike Ride — an annual cycling event that raises money for rare disease research. Each year, our riders hit the road (and the stationary bike) to fund groundbreaking CADASIL research grants. Below is our complete history.

2026
2026 Million Dollar Bike Ride
$106,362

Team CADASIL $106,362 surpassed our goal of $100,000 , demonstrating the growing support and dedication of our community.
Grants Funded:To be determined
Funding Period: Feb 1, 2027 - Jan 31, 2028
2025
2025 Million Dollar Bike Ride
$80,000

Team CADASIL $80,000 ."
Awardee: Osama Harraz, MSc, Ph.D
Title: Combating Neurovascular Degeneration in CADASIL by Targeting Piezo1”
Grant Amount:$80,0006
Funding Period: Feb 1, 2026 - Jan 31, 2027
2024
2024 Million Dollar Bike Ride
$101,776

Team CADASIL returned for another year of pedaling for progress. The community rallied once again to push fundraising totals higher and bring more attention to CADASIL research.

Awardee: Michael Wang, M.D Ph D., University of Michigan
Title: Small Molecule Inhibiiton of Notch3 Confomational Alterations
Grant Amount:$101,776
Funding Period: Feb 1, 2025 - Jan 31, 2026
2023
2023 Million Dollar Bike Ride
$109,856

Team CADASIL took part in the 2023 MDBR, continuing the annual tradition of raising funds specifically designated for CADASIL pilot research grants through the University of Pennsylvania program.

Awardee: Helena Karlstrom, Karolinska Institutet
Title:Immunotherapy and Improved Diagnosis and Prognosis of the Small Vessel Disease CADASIL
Grant Amount:$109,856
Funding Period:Feb 1,2024 - Jan 31,2025
2022
2022 Million Dollar Bike Ride
$117,734

The 2022 ride brought renewed energy to the team. Funds raised went directly toward MDBR pilot research grants, keeping CADASIL science moving forward.

Awardee:, MD, University of Colorado
Title:Advance in PIP2 Treatement to Restore Capillary Blood Flow
Grant Amount:$117,734
Funding PeriodFeb 1,2023- Jan 31,2024
2021
2021 Million Dollar Bike Ride
$60,228

2021 marked another strong showing for Team CADASIL. Riders and supporters across the community helped push cumulative totals higher, funding meaningful pilot research.

Awardee:Israel Fernandez Cadenas, Fundacio Privada Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Title:Single-Nuclei RNA-Seq for CADASIL Understanding and Therapeutic Target Discover
Grant Amount:$60,228
Funding Perios:Feb 1, 2022 - Jan 31,2023
2021
2021 Million Dollar Bike Ride
$60,228

2021 marked another strong showing for Team CADASIL. Riders and supporters across the community helped push cumulative totals higher, funding meaningful pilot research.

Awardee:Saskia Lesnik-Oberstein, Leiden University Medical Center
Title:Modeling CADASIL iwth Patient IPSC BASED 3D Vessel-on-Chip
Grant Amount:$60,228
Funding Perios:Feb 1, 2022 - Jan 31,2023
2020
2020 Million Dollar Bike Ride
$82,795

class=" year-card-description"> 🏆 Milestone: Over $82,000 in CADASIL pilot research grants were awarded following the 2020 ride — the largest grant round to date.

Awardee:Masay Koide, University of Vermont Larner College of Medicine
Title:HB-EGF/EFR Signaling in Capllary Dysfunction in CADASILMbr> Grant Amount:$82,795
Funding Period:Feb 1, 2021-Jan 31, 2022
2019
2019 Million Dollar Bike Ride - the beginning
$81,951

2019 marked Team CADASIL's very first participation in the Million Dollar Bike Ride. This inaugural effort planted the seed for what has grown into a beloved annual tradition — and an important funding pipeline for CADASIL research.

Awardee:Fabrice Dabertrand, MD, University of Colorado
Title:Pericyte Contractility in CADASIL
Grant Amount:$81,951
Funding Period:Feb 1, 2020 - Jan 31,2021 Note: